Statement of claims: Treatment and prevention of flea (Ctenocephalides felis) infestations for up to 6 months Treatment and control of paralysis tick (Ixodes holocyclus) for 6 months Treatment and control of brown dog tick (Rhipicephalus sanguineus) for 12 weeks. Rapid onset of action kills newly emerged adult fleas before they lay eggs Reduces incidence of flea allergy dermatitis (FAD) by controlling adult fleas BRAVECTO Spot-on contains fluralaner, a member of the antiparasitic class of isoxazoline-substituted benzamide derivatives. Fluralaner acts antagonistically on arthropods ligand¬gated chloride channels (GABA-receptor and glutamate-receptor). BRAVECTO Spot-on is effective against fipronil-resistant strains of fleas. BRAVECTO Spot-on can be used in breeding, pregnant and lactating dogs. Spot-on kills pre-existing and new infestations of paralysis ticks (Ixodes holocyclus) for 6 months. BRAVECTO Spot-on provides effective control of fleas on dogs within 8 hours of administration, and subsequently maintains persistent efficacy against flea re-infestations for 6 months following application. The flea life cycle can be broken by the rapid onset of action and the long-lasting efficacy against adult fleas on the dog. Newly emerged adult fleas on a dog are killed before viable eggs are produced BRAVECTO Spot-on effectively controls environmental flea populations in areas to which the dog has access.