Dose & Administration 30 – 40 pills twice daily, half to one hour away from food. In severe cases the dosage may be increased up to 50%, e.g. 50 pills twice daily or 30 - 40 pills, three times daily. Course of treatment: 2 – 4 months Cautions/Contra-Indications Avoid caffeine containing beverages (i.e. coffee, tea, cola drinks, guarana), especially in the afternoon. Caution in patients using sedative-hypnotic medications.