What Is Creatine Monohydrate? Creatine monohydrate is an organic compound that helps facilitate recycling of ATP in muscle and brain tissue and is found in vertebrates. It was first discovered in 1832 by Michel Eugne Chevreul, and the first evidence of its benefits on the muscles was found in 1912 by Harvard University researchers. Creatine became available as a dietary supplement in 1993, and since then it has become one of the most widely studied supplements. Creatine is commonly taken by athletes and bodybuilders and has become a staple of workout supplements. Creatine Monohydrate Benefits Creatine is among the most well-researched and effective supplements. Unlike other supplements that only affect advanced athletes, creatine benefits you regardless of your fitness level but is known by many to be the worlds most effective supplement for high-intensity sports. It can help with exercise performance by rapidly producing energy during intense activity. Creatine may also help with cognitive function and support the brain.