Activates the cholinergic anti-inflammatory pathway (CAP) which reduces immune activation, a driver of gut dysfunction and systemic inflammatory conditions. Stimulation of the vagal nerve supports healthy communication between the enteric nervous system and the brain in inflammatory disorders. A unique herbal and nutrient formulation containing berberine and zinc carnosine. Gut InflamX's unique herbal and nutrient combination provides anti-inflammatory support for systemic conditions where GI dysfunction is present. Studies in vitro demonstrate that zinc, vitamin D, Boswellia serrataand berberine all support intestinal mucosal barrier function via several mechanisms including antioxidant action, cell membrane repair and tight junction support. Boswellia serrata is traditionally used in Ayruvedic medicine to relieve gastrointestinal pain, digestive discomfort, and GI inflammation. Zinc carnosine's anti-inflammatory and antioxidant actions are thought to be responsible for its beneficial effects in the maintenance, prevention, and treatment of the mucosal lining and other epithelial tissues. In addition, a review found that berberine has a protective effect and reduces cell permeability, and protects the intestinal mucosal epithelial barrier from TNF - a damage.