Dogtown is a shelter for stray dogs, misbehaving dogs, and discarded robot dogs, whose owners have outgrown them. Buster is a big-hearted dog who couldn't attract more trouble if he tried. Stewie is a huge, loveable dog whose ex-owner said he was mean. And Mouse is a mouse, who has the run of Dogtown and happens to be Buster's best friend in the world. Determined to help Buster find his forever home, Mouse, Stewie, Buster and a robot-dog called Smokie embark on a bold quest in search of the perfect family. With peril, adventure and lots of laughter along the way.