America, 1899. It is the beginning of the end of the Wild West era, with lawmen hunting down the last remaining outlaw gangs. Those who do not surrender or succumb are simply eliminated. When a robbery goes wrong in the town of Blackwater, Arthur Morgan and the Van der Linde gang are forced to flee. With federal agents and the best bounty hunters in the nation hot on their heels, the gang must rob, steal, and fight to survive in the rugged heartland of America. As internal divisions threaten to tear the gang apart, Arthur must make a choice between his own ideals and loyalty to the gang that raised him.