Directions for best results Use sparingly at first. Apply a small amount to the required area (1 - 2cm length should be enough for a small area) and massage in lightly until absorbed. Percutane Pain Relief Cream may produce a warm sensation which is part of the beneficial effect. Only a small amount is required for prolonged results. Depending on the type of pain you are experiencing you may need to use it for 1 week or even up to 4 weeks to obtain the full effect. Wash hands thoroughly with soap and water after use (if hands are not the treatment site) or use gloves to apply. If using for arthritis in your hands apply Percutane Pain Relief Cream and wait 20 to 30 minutes before washing. Avoid eye or sensitive area contact during this time. Exercise or a hot bath or shower can reactivate the beneficial warming process.