Save money (and the planet by helping to reduce plastic waste by 74%) with Bio-Performance Skin Filler Refills. When you’re ready for a refill, simply add your existing caps and pumps to your fresh bottles and get back to your skin care routine, stat. A day and night duo, Bio-Performance Skin Filler optimises your circadian rhythm to seriously plump up skin and reduce the appearance of fine lines. Based on 30 years of research in hyaluronic acid, Shiseido’s innovative MolecuShift technology compacts this hydrating hero and delivers it deep into the skin while you sleep. The hyaluronic acid then expands to its original size to push skin out from within. A lifted, radiant appearance with youthful fullness.