Latest upgraded version adds Zuo Shiseido’s patented ingredient [Pure Retinol] "High Purity Vitamin A"which is approved by the Japanese Ministry of Health and Welfare. The only certified effective anti-wrinkle ingredient can improve wrinkles from the surface deep into the skin! The product can be used on the delicate eye and lip areas to directly act on fibroblasts, promote the production of type I collagen and type III collagen, and produce hyaluronic acid in both the dermis and epidermis to achieve "bright and shiny" beautiful skin. How to use: At the end of your morning and evening skincare routine, take a small pearl and place it on your fingertips. Gently apply it to areas where you worry about wrinkles, such as around the eyes and mouth. If used in the morning, use cosmetics with UV protection after use to protect the effects of retinol.