Originally born as a human, his encounter with a female ghoul under the name of Kamishiro Rize forced him to undergo emergency surgery procedures after his assault by her. Cunning and manipulative, Rize uses her charms and Kaneki's attraction toward her as a means of getting her next "meal." After the attack, Kaneki is rushed to the hospital in a half-dead state with Rize. A doctor of the name Kanou, who secretly experiments with ghouls, humans, and half-ghouls, transplants what Kaneki believes to be a kidney into his body as a means of saving his life in the dire situation. Soon he learns that he had part of Rize's kagune transplanted into him, becoming the first of many human-ghoul experiments Kanou will conduct. Two years following his defeat against Kishou Arima, he lived under the identity of Haise Sasaki, a Rank 1 Ghoul Investigator who served as the mentor of the CCG's Quinx Squad.