Contains 5% benzoyl peroxide (bpo) a very effective antibacterial lotion for the treatment of acne and acne-prone skin. This micronized benzoyl peroxide solution assists by killing acne causing bacteria (p. Acnes bacteria) and helping to clear dead skin and oil from pores. Jan marini skin research uses ultra-micronized bpo to get even greater penetration into the skin while minimizing sensitivity and irritation common with many benzoyl peroxide solutions.cleanse the skin thoroughly before applying 5% benzoyl peroxide cream. Cover the entire affected area with a thin layer one to three times daily. Because excessive drying of the skin may occur, start with one application daily, then gradually increase to two or three times daily if needed or as directed by a physician. If bothersome dryness or peeling occurs from the 5% benzoyl peroxide lotion, reduce application to once a day or every other day. If going outside, apply sunscreen after using this product. If irritation or sensitivity develops, stop use of this benzoyl peroxide cream and ask a physician.