Fem-Dophilus contains two patented and clinically documented probiotic strains, lactobacillus rhamnosus, gr-1 and lactobacillus reuteri, rc-14, discovered and developed by dr. Gregor Reid and dr. Andrew Bruce at Urex biotech. Over 25 years of research supports the oral use of gr-1 and rc-14 to colonize and promote healthy vaginal and urinary tract health. A special manufacturing process protects the probiotic strains in Fem-Dophilus from stomach acid and enhances probiotic bacterial survival to the lower intestine. Fem-Dophilus does not require refrigeration and can be stored at room temperature. Refrigeration will, however, extend the shelf life. Avoid temperatures above 77 Degree (25 DegreeC).