Fem-Dophilus contains two patented and clinically documented probiotic strains, Lactobacillus rhamnosus, GR-1 and Lactobacillus reuteri, RC-14, discovered and developed by Dr. Gregor Reid and Dr. Andrew Bruce at Urex Biotech. Over 25 years of research supports the oral use of GR-1 and RC-14 to colonize and promote healthy vaginal and urinary tract health. * A special manufacturing process protects the probiotic strains in Fem-Dophilus from stomach acid and enhances probiotic bacterial survival to the lower intestine.* n one of the randomized clinical trials, 75% of women in the GR-1/RC-14 probiotic group experienced significant improvement in vaginal flora composition, while only 34% of women in the placebo (non-probiotic) group experienced similar improvement.